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Please Note: Due to volume considerations, not all questions can be answered. Questions most likely to be answered will be those of general interest to a broad group of visitors to this forum. Questions pertaining to a specific case; requests for diagnosis, medical advice, or second opinion; or requests for opinions about untested alternative therapies will generally not be answered.

The participation of Dr. Ewald Horwath in this Forum is made possible by Boehringer Ingelheim.

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HIV subtypes and testing
Aug 21, 2008

Hey Doc!

I had a possible exposure in Thailand and 2.5 weeks later I got tested via PCR DNA in the US. I read a study published in a medical journal (2001) that subtype E (A/E) sensitivity was as low as 70% (whereas B was 100%). "E" would have been the subtype of possible contraction. I had flu like symptoms two days after the test so my viral load would have been high (assuming it was HIV). Do you have any information on the accuracy of subtype detection via US PCR DNA tests (currently)?

I am waiting to see a neurologist, but I am having symptoms of peripheral neuropathy, including urinary problems that were untreated by two weeks of doxycycline. A person experiencing HIV associated PN in early stages would almost always yield a positive ELISA, right?

I will do an ELISA next week, which will be 1.5 months post exposure. How accurate are the oraquick tests at detecting subtypes?

I am very thankful for all your help on this forum. I have been reading quite a bit over the past week. Thanks again :)

Response from Dr. Horwath

Peripheral neuropathy occurs in people who have AIDS with declining CD4 counts and rising viral loads. It does not occur weeks or months after the initial infection.

PCR tests are not appropriate screening test for HIV. The most appropriate screening tests are the HIV antibody tests. The modern versions of the ELISA test can detect HIV antibodies 4-6 weeks after exposure, but it is best to get tested 12 weeks after exposure to get the most accurate result.



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