Im 58 and Ive had HIV longer than anyone I know, at least 23 years. Ive developed resistance to everything Ive taken so far. My doctor wants to me to try some of the new drugs just approved in the last year, selsentry or isentris or something. Is there a good chance these drugs will be effective for me, even though I've been around the block so many times?

There are several new drugs for people with resistant virus, including Selzentry (a CCR5 blocker), Isentress (integrase inhibitor) and intelence (a new NNRTI). These drugs may well work for you and will work best if all combined together, typically with a boosted protease inhibitor such as darunavir. Several tests need to be done to determine if each drug is active against your virus. A resistance test (and review of old resistance tests) to determine which PI is best, whether intelence will be active and if any nucs are still active, and a tropism test to determine of Selzentry is active. It generally takes about a month to get these results back. My general view is that you should aim to take as many of these drugs as is active (which could be all 4) to give the best chance of success. One general comment is that all thses drugs are pretty well tolerated, Selzentry and Isentress looked little different to dummy pills in their main studies, so each extra med is likely to increase the chance of success without adding side effects. The drugs should all work well regardless of your age, its the taking them reliably that counts.